Protein Dynamics and Stability: Universality vs. Specificity

Speaker
Prof. Rony Granek, Department of Biotechnology Engineering, Ben-Gurion University of The Negev, Israel
Date
03/04/2012 - 18:00 - 17:00Add to Calendar 2012-04-03 17:00:00 2012-04-03 18:00:00 Protein Dynamics and Stability: Universality vs. Specificity In this talk, I shall discuss the fractal characteristics of natively folded proteins and their relation to protein dynamics and function. A universal equation of state, describing the relation between the spectral and fractal dimensions of a protein and the number of amino acids, will be shown. Using structural data from the protein data bank of about 5,000 proteins, and the Gaussian network model, I shall demonstrate that the equation of state is well obeyed. Various dynamical quantities will be shown to evolve anomalously. The effect of the hydrodynamic interaction between amino acids will be also elucidated. Finally, I will discuss the dynamic structure factor S(k,t) of proteins at large wavenumbers k, that are sensitive to the protein internal dynamics, and demonstrate its stretched exponential decay.   Physics Department (Building 202), room 301, Bar-Ilan University המחלקה לפיזיקה physics.dept@mail.biu.ac.il Asia/Jerusalem public
Place
Physics Department (Building 202), room 301, Bar-Ilan University
Abstract

In this talk, I shall discuss the fractal characteristics of natively folded proteins and their relation to protein dynamics and function. A universal equation of state, describing the relation between the spectral and fractal dimensions of a protein and the number of amino acids, will be shown. Using structural data from the protein data bank of about 5,000 proteins, and the Gaussian network model, I shall demonstrate that the equation of state is well obeyed. Various dynamical quantities will be shown to evolve anomalously. The effect of the hydrodynamic interaction between amino acids will be also elucidated. Finally, I will discuss the dynamic structure factor S(k,t) of proteins at large wavenumbers k, that are sensitive to the protein internal dynamics, and demonstrate its stretched exponential decay.

 

תאריך עדכון אחרון : 26/03/2012