Jamming and Geometry in Epithelial Biology

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QUEST Center event
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Speaker
Lior Atia
Date
11/12/2018 - 10:00
Place
9th floor seminar room, Nano building (206)
Abstract

As an injury heals, an embryo develops, or a carcinoma spreads, epithelial cells systematically change
their shape. In each of these processes cell shape is studied extensively whereas variability of shape
from cell-to-cell is regarded most often as biological noise. But where do cell shape and its variability
come from? In this talk I will show that cell shape and shape variability are mutually constrained through
a relationship that is purely geometrical. That relationship is shown to govern processes as diverse as
maturation of the pseudostratified bronchial epithelial layer cultured from non-asthmatic or asthmatic
donors, and formation of the ventral furrow in the Drosophila embryo. Across these and other epithelial
systems, shape variability collapses to a family of distributions that is common to all. That distribution, in
turn, is accounted for by a mechanistic theory of cell-cell interaction showing that cell shape becomes
progressively less elongated and less variable as the layer becomes progressively more jammed and
solid-like. These findings suggest that, in diverse multicellular organisms, jamming behavior sets
overriding geometrical constraints. Such constraints along with the well-recognized role of cellular
geometry as a fundamental regulator of cell behavior, may provide the missing physical picture of
cancer invasion and growth. This perspective points to the hypothesis that the malignant primary tumor
is unjammed and fluid-like, and thus, through the agency of elongated cell shapes, may shed clusters of
metastasizing cells and retain high mitotic capacity even in dense cell packing.