Understanding the variability of growth in single cells: from bacteria to mammalian cells

Seminar
QUEST Center event
No
Speaker
Prof. Nathalie Q. Balaban
Date
09/01/2017 - 12:30Add to Calendar 2017-01-09 12:30:00 2017-01-09 12:30:00 Understanding the variability of growth in single cells: from bacteria to mammalian cells Noise analysis in biological systems has greatly increased our understanding of the underlyingcellular processes. Noise in the cell division process is often assumed to be responsible for variability in cell cycle duration, and to underlie heterogeneous responses of bacteria to antibiotics, as well as of cancer cells to drugs. We show that variability of growth in bacteria can evolve under fluctuating environment.   More generally, we ask whether we can differentiate between stochastic and deterministic control of cell division variability. Using long-term time lapse microscopy to follow thousands of divisions and tools from non linear dynamics analysis, we show that the variability in cell-cycle duration in mammalian cells, which at first glance seems dominated by noise, is in fact controlled by a deterministic factor.   Building 202 (Physics) room 301 Department of Physics physics.dept@mail.biu.ac.il Asia/Jerusalem public
Place
Building 202 (Physics) room 301
Abstract

Noise analysis in biological systems has greatly increased our understanding of the underlyingcellular processes. Noise in the cell division process is often assumed to be responsible for variability in cell cycle duration, and to underlie heterogeneous responses of bacteria to antibiotics, as well as of cancer cells to drugs.

We show that variability of growth in bacteria can evolve under fluctuating environment.  

More generally, we ask whether we can differentiate between stochastic and deterministic control of cell division variability. Using long-term time lapse microscopy to follow thousands of divisions and tools from non linear dynamics analysis, we show that the variability in cell-cycle duration in mammalian cells, which at first glance seems dominated by noise, is in fact controlled by a deterministic factor.

 

Last Updated Date : 01/01/2017