Dynamics and mechanics of moving cells
Prof. Kinneret Keren, Dept. of Physics, Technion
24/12/2012 - 10:30 - 12:00
Room 301, Physics Bld. 202
Cell movement is driven by a spatially extended, self-organized, mechanochemical machine consisting of numerous actin polymers, accessory proteins and molecular motors. This impressive assembly self-organizes over several orders of magnitude in space and time, from the fast dynamics of individual molecular-sized building blocks to the persistent motion of whole cells over minutes and hours. We focus on the mechanisms underlying this remarkable self-organization using the simplest available model systems. We combine quantitative analysis of cell morphology and spatio-temporal dynamics at the molecular level with biophysical measurements, toward the goal of understanding how global cell shape and movement are determined. Our results feed into and direct the development of quantitative theoretical models of moving cells.